منابع مشابه
Acidity Theory of Atherosclerosis
Here is proposed a new hypothesis where acidity, evoked by stress, has an important role in the generator mechanism of atherosclerotic lesions, giving a new perspective for the understanding of its etiology and pathogenesis. The acidity theory of atherosclerosis is inside the response to injury concept. It has the following sequence of events: I. Sympathetic dominance by continuous stress plus ...
متن کاملRegulation of Organelle Acidity
Intracellular organelles have characteristic pH ranges that are set and maintained by a balance between ion pumps, leaks, and internal ionic equilibria. Previously, a thermodynamic study by Rybak et al. (Rybak, S., F. Lanni, and R. Murphy. 1997. Biophys. J. 73:674-687) identified the key elements involved in pH regulation; however, recent experiments show that cellular compartments are not in t...
متن کاملAcidity of two-dimensional zeolites.
Hybrid quantum mechanics:molecular mechanics (QM/MM) calculations of absolute deprotonation energies are performed with periodic boundary conditions for Brønsted sites of aluminosilicate bilayers with various Al/Si ratios (two-dimensional zeolite). The supercell method is applied and density functional theory is used. Much lower values are obtained (1042, 1069 and 1091 kJ mol(-1) for Al/Si = 1/...
متن کاملIntracellular Acidity in Valonia
The very large cells of the marine green alga Valonia macrophysa permit one to obtain several cubic centimeters of fluid from the central vacuole of a single cell (cf. Wodehouse, 1917), without involving appreciable alteration in the composition of the cell-sap through protoplasmic 'injury during the process of extraction (cf. Chambers, 1917). Estimations have been made of the acidity of this c...
متن کاملMathematical modelling of tumour acidity.
Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as the existence of the benign steady state, or predicted incorrectly the size of the inter-tissue gap. Here we show that taking proper account of quiescence ameliorates these drawbacks as well as rev...
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ژورنال
عنوان ژورنال: Nature
سال: 1939
ISSN: 0028-0836,1476-4687
DOI: 10.1038/1431068a0